Non-league Kidderminster are seen as 9/1 outsiders to knock Sunderland out of the FA Cup whilst Hull meet a familiar face in Phil Brown when they meet Southend as the fourth round gets underway.
The FA Cup’s reputation for giant-killing is known worldwide and two of the lowest ranked sides left in the chance will get the chance on Saturday to steal the headlines with victory over top flight opponents.
Kidderminster are the only non-league side left in the cup and they find themselves with it all to do as they take on Capital One Cup finalists Sunderland at the Stadium of Light.
On their path to the last 32, The Harriers overcome Sutton United and AFC Newport before they defeated League One side Peterborough 3-2 in the last round.
One problem that will face The Harriers going into the tie is that they will no longer have in-form striker Joe Lolley who had scored 11 goals this season for the side before joining Huddersfield a week ago.
Despite his absence, the Conference National side will still have Michael Gash as one of their most prominent attacking threats as the striker has scored in his last two games for the club.
However, they take on a Sunderland side who are virtually unbeaten in 2014 and have yet to lose in cup competition this season including a 3-1 victory over Carlisle in the last round.
After being in action mid-week, Gus Poyet is likely to make several changes in the squad with the likes of Vito Mannone, Steven Fletcher and Adam Johnson all likely to be rested for the game.
It means that Fabio Borini is likely to come into the squad to lead the attack whilst the experience of Andrea Dossena and Lee Cattermole could also prove to be useful in navigating past a feisty opponent looking for an upset.
In the best of the other games, Hull will find themselves in a similar position as they look to avoid a shock defeat when they travel to Roots Hall to face League Two side Southend and former boss Phil Brown.
The Tigers booked their pace in the fourth round after knocking out Middlesbrough 2-0 in what has been their only win so far in 2014.
Steve Bruce will be keen to field a full strength side in order to help them get through a tough tie although Tom Huddlestone is suspended after getting sent off last weekend.
Phil Brown will be eager to cause his former side some anguish and he will hope to add to a growing list of teams knocked out by The Shrimpers which includes the likes of Morecambe, Chesterfield and Millwall.
Southend will no doubt hope that Freddie Eastwood’s experience will give them an added edge against Premier League opposition as the Welsh International has already scored 8 times as well as being known for the infamous goal that knocked out Manchester United of the League Cup back in 2007.
With many of the smaller clubs looking to make the headlines, it means that Premier League sides need to be extra careful going into the Fourth Round of the FA Cup.