Manuell Pelegrini and his Manchester City side face a must win victory, with Roma v Man City live stream, odds and match preview from Footybunker.com.
Roma host Manchester City in the fixture that will almost certainly decide who qualifies second with Bayern Munich from their Champions League group.
Sergio Aguero’s hat-trick at home to Bayern Munich has given Manchester City hope of reaching the last 16, when their chances appeared slim.
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The Argentine forward scored a last minute winner at the Etihad, which came hours after the news Roma conceded late on away to CSKA Moscow to draw.
Should Roma have held on and City not beaten Bayern, then Roma would have already booked their place in the next round.
Manchester City come into the game in good form, having recorded a four consecutive Premier League wins.
Rudi Garcia opted to rotate his squad for the home match with Sassuolo, which back fired as they dropped points at home for the first time this Serie A season.
Earlier in the group stage, Francesco Totti cancelled out an Aguero penalty at the Etihad with the shares spoiled.
Roma v Manchester City Team news
Totti was rested on the weekend, however will return for Roma’s crucial do or die Champions League match.
Kevin Strootman has featured recently following his lengthy injury, although looks set for a bench role.
Manchester City will be without three key players through injury in the form of Vincent Kompany, David Silva and Aguero.
Aguero went off injured in the weekend win over Everton and looks set to miss a month of action.
Yaya Toure is also suspended following his straight red card at home to CSKA Moscow recently.
Fernandinho will return from his own ban and partner the fellow Brazilian Fernando in central midfield.
Roma: De Sanctis; Florenzi, Manolas, Astori, Cholevas, Nainggolan, De Rossi, Keita, Gervinho, Totti, Ljajic
Manchester City: Hart; Zabaleta, Demichelis, Mangala, Clichy; Fernando, Fernandinho; Navas, Nasri, Milner; Dzeko