Its Arsenal v Liverpool, Everton v West Brom, Norwich Spurs, Man Utd Southampton & Reading v Chelsea as Paddy Power release the latest odds on Wednesday’s coupon.
There are six games in total from the Premier League tonight and the points up for grabs mean plenty in terms of the title race, a European spot and the fight to stay in the league.
Three encounters get underway at 7.45PM, with the pick of them being Arsenal v Liverpool at the Emirates Stadium.
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The away side have a chance to move level with their opponents in this one with a win, which would put them right into Champions League contention.
However, the Gunners need all three points themselves to remain within touching distance of Tottenham Hotspur in fourth.
Both sides like to play an attacking style of football and have not found scoring goals a problem in recent weeks, so we could be in for a cracker here.
Brendan Rogers’ side came unstuck in the FA Cup against Oldham last weekend and while the Gunners are not defensively solid , in Theo Walcott, Olivier Giroud and Lukas Podolski they have three world class forward players, who could make the difference.
The 6/4 available for the home win is sure to see plenty of interest.
Tottenham are also in action as they make the journey to Norwich City. Spurs will fancy their chances of coming out on top here as Norwich have taken just one point from a possible 18 in the league and were beaten by Luton Town in the FA Cup last time out.
In the top flight, the North Londoners have been superb in recent weeks, but they have to bounce back from their FA Cup exit at the hands of Leeds United.
The pressure is definitely mounting on Chris Hughton as the Canaries are now without a win in six and were humiliated 5-0 at Anfield in their last Premiership outing.
The one saving light for Norwich is that Spurs will be missing Emmanuel Adebayor, who is away at the Africa Cup of Nations and Jermain Defoe, who is struggling with injury. The draw at 12/5 looks the safest bet in this one.
Everton and West Bromwich Albion lock horns on Wednesday as well and this should be a very entertaining 90 minutes.
The Toffees are just three points adrift of the top four, so know what a win could do for their Champions League hopes, whereas West Brom have not won in four and are in danger of slipping into the bottom half soon.
The early season goals of Shane Long seemed to have dried up and with Peter Odemwingie desperate to seal a move away from the club, possibly to QPR, things are not rosy behind the scenes, as Everton look accumulator material to win at 4/7.
There are then another three matches at 8PM and Manchester United might have their lead cut to just two points when they take on Southampton at Old Trafford.
With the way the Red Devils are playing at the moment, it is tough to see anything but a home win here. Sir Alex Ferguson might not know what to expect from the Saints though as Mauricio Pochettino has had over a week to get his ideas across.
The Premiership league leaders have an emphatic home record at the moment and the return of Nemanja Vidic has tightened things up at the back. The 1/4 on the home win is for the big hitters only.
Chelsea need to claim a victory when they head to Reading on Wednesday to maintain their healthy lead over Spurs in fourth.
It has been a strange few weeks for the Blues and the travelling fans are sure to give Rafael Benitez some stick if the performance isn’t right here.
The European Champions must be at their best as well as Reading have found a new lease of life in recent weeks and won two of their last three, which has moved them to within just a point of safety.
Adam Le Fondre is scoring for fun at the moment and momentum is definitely with the Royals, with their price of 6/1 looking far too big to ignore to heap more misery on Benitez.
Finally, there is a London derby taking place as Fulham host West Ham United. Neither of these two are in good form at the moment and know a couple more defeats would see them dragged into the relegation battle – so this is a huge game.
West Ham won this fixture 3-0 earlier in the season and a repeat performance is just what Sam Allardyce will be after.
It should be a superb night of action in the Premier League.