Burnley and QPR are at equal odds as the two runaway leaders clash at Turf Moor meanwhile the South Yorkshire derby could have a significant impact at the bottom of the table.
Both Burnley and QPR have been virtually unstoppable so far this season and the top two sides will meet in Lancashire knowing that the winner will end the day as the leader of the standings.
Burnley has been the side to beat in the Championship so far and the league leaders have looked almost unstoppable winning 9 out of their first 12 games this season.
Boss Sean Dyche will be boosted by the return to full fitness of Kieran Trippier who was a concern going into last week’s game aginast Ipswich but is likely to start on Saturday afternoon.
Apart from that, Burnley have virtually a full squad to choose from although Ross Wallace’s long term injury problems still put the Scotsman out of contention for as starting place.
QPR have been on fire since they were relegated from the Premier League and the second placed side are the only unbeaten team left in The Championship nearly a quarter of the way into the season.
QPR will be boosted by the return of striker Andy Johnson who has missed the last month out with a thigh injury and could come straight into the squad as a replacement for the injured Bobby Zamora.
Meanwhile, former Newcastle defender Oguchi Onyewu could make his debut for QPR as the American signed on a free deal earlier this week and could act as a replacement for the injured Nedum Onuoha.
Heading further east, there is also a lot riding in the South Yorkshire derby between Barnsley and Sheffield who are both rooted to the foot of the table in 22nd and 23rd place respectively.
Barnsley will be brimming with confidence having picked up their first win in seven games against Middlesbrough last weekend and manager Gary Flitcroft are likely to stick with the same side that picked up the three points for the relegation candidates.
Sheffield Wednesday will be without Portuguese Jose Semedo who is suspended after getting sent off against
Bolton last weekend whilst Matt Fryatt is set to make his last appearance for Wednesday before his loan spell ends at the end of the month.
With a lot riding on both games, it could mean that we see a dramatic change at both ends of the table and teams start to learn of their possible fates for the rest of the season.