Bayern Munich remain 1/2 favourites with Paddy Power to defeat Manchester City and cement their place at the top of Group B.
Manchester City will know that they will need to overcome the odds if they are to stand any chance of deposing Bayern Munich on Tuesday night.
So far this season, Bayern are undefeated in all competitions and the defending Champions League winners sit on top of the group with a three point gap over City.
After picking up an injury late last week, Pep Guardiola will be without Dutch winger Arjen Robben for the tie as his knee problems have ruled him out for the rest of 2013.
This shouldn’t be a problem for Bayern though who could rotate a few players around giving the likes of Toni Kroos and Mario Gotze the chance to showcase their attacking potential to the world.
Manchester City have managed to extinguish the demons that have haunted them in Europe for the past two seasons and qualify for the knockout rounds for the first time in three years.
With nothing on the line, Manuel Pellegrini could rotate some of his players before Saturday’s big game against Arsenal which could mean David Silva could feature for the first time in four weeks after returning from a calf injury.
There could also be spots for Martin Demichelis and Alvaro Negredo in the squad as the likes of Vincent Kompany and Sergio Aguero are rested before Saturday’s crunch tie.
The other game is Group B will see CSKA Moscow and Viktoria Plzen face off against each other in the Czech Republic with the winners likely to gain a place in the Europa League.
Plzen are currently bottom of Group B but a 3-0 win against their Russian opponents would see the Czech champions stay in Europe at the expense of third-placed Moscow.
However, their Russian opponents have the advantage going into tomorrow night’s clash at the Doosan Arena having won the reverse fixture 3-2 when the sides met back in October.
Despite the battles going on in the bottom half of the group, Manchester City and Bayern will both be keen to pick up three points and avoid some of their main rivals heading into the last 16.