Manchester United will be looking to end a run of three games without a win when they host Crystal Palace.
Palace themselves are without a win in four games and have dropped to 17th in the Premier League, following their recent defeat.
Manchester United went down to a 1-0 defeat away to their biggest rivals Manchester City, with Chris Smalling’s dismissal costing the visitors.
Smalling was sent off in the first period for two needless yellow cards and Sergio Aguero’s goal turned out to be the winner.
Palace lost at home to Sunderland 3-1, who moved above the Eagles following Monday nights win!
Steven Fletcher scored twice in the win, including a superb opener, as Sunderland recorded a vital victory.
Last season Manchester United won both meetings 2-0, with Robin van Persie opening the scoring in both from the spot.
Ironically in both fixtures, Wayne Rooney scored superb second goals to seal the victories, including a free-kick at Old Trafford.
Manchester United have a defensive crisis once again, with Rafael, Phil Jones, Chris Smalling, Jonny Evans and Marcos Rojo all out.
Antonio Valencia will continue at right back, whilst Michael Carrick could be set for a makeshift central defensive role.
Radamel Falcao is still a massive doubt for United, meaning Van Persie will again lead the lead line.
Mile Jedinak was sent off in the Sunderland defeat and is suspended for the trip to Old Trafford on Saturday.
James McArthur will be hoping to feature after a period on the sideline, whilst Adlene Guedioura looks set to start.
Marouane Chamakh may be dropped so Palace can play a five man midfield, with the former Red Frazier Campbell leading the line.
Manchester United: De Gea; Valencia, McNair, Carrick, Shaw; Blind, Herrera; Januzaj, Rooney, Di Maria; Van Persie
Crystal Palace: Speroni; Kelly, Delaney, Hangeland, Ward; Puncheon, McArthur, Ledley, Guedioura, Bolasie; Campbell