The Italian international made the £6m move from Inter over the summer but picked up a knee injury preventing him from making his full debut in Newcastle colours.
Santon played against Swansea in a reserve match on Wednesday and will be hoping to start against Wolves on Saturday.
The departure of Jose Enrique to Liverpool prompted Alan Pardew to purchase a full-back of international standard and at 20 years-old, Santon fits the bill.
Speaking to the Newcastle Evening Chronicle, the youngster noted: “I will give everything on the pitch and show that I am a good player.”
He added: “But I can enjoy life here at Newcastle and I am looking forward to playing in front of a packed house at St James’ Park as soon as I can.”
Having already been capped seven times for the Italian national side and played Champions League football with Inter Milan, the starlet provides an impressive alternative as an attacking wing-back after the Magpies were inches away from signing Erik Pieters of PSV.
Santon will be battling with Ryan Taylor for the starting berth at left-back, as Newcastle look to continue their unbeaten season.