The top two sides in Group G meet, as Germany take on the United States.
A draw would be good enough for the pair to qualify, which would leave their tally of five points uncatchable by Ghana and Portugal.
In another interesting side note, Jurgen Klinsmann will manage against the nation of his birth, and the country he managed at the 2006 World Cup.
United States were literally seconds away from booking their place in the last 16, when Silvestre Varela headed home a Cristiano Ronaldo cross.
Goals from Jermaine Jones and Clint Dempsey had earlier turned the game on its head, after the US had fell behind to an early Nani strike.
Germany themselves were involved in a brilliant 2-2 draw, after Miroslav Klose’s equaliser sent him level with Ronaldo for all time World Cup goals.
Mario Gotze had given Germany the lead early in the second period, however Andre Ayew and Asamoah Gyan gave the Black Stars a surprise lead.
Germany have won six of the nine internationals, however the United States did record a surprise 4-3 win the last time the pair met.
The United States are likely to name the same starting XI, meaning Dempsey will start again on his own up front.
Fabian Johnson has been impressive done the right hand side and was a consistent threat against Portugal from full-back.
Aron Johansson will be hoping to come in, however against a strong German midfield, Klinsmann is likely to keep the same formation.
Shkodran Mustafi replaced Jerome Boateng at half-time in the Ghana draw and the former Everton full-back may well start on Thursday.
Despite his World Cup record equalling goal, Klose is likely to be named as a substitute again, with Thomas Muller leading the line.
USA (4-5-1): Howard; Beasley, Besler, Cameron, Johnson; Beckerman, Jones, Bradley, Bedoya, Zusi; Dempsey Germany (4-1-2-3): Neuer; Mustafi, Mertesacker, Hummels, Höwedes; Lahm, Khedira, Kroos; Muller, Ozil, Gotze